AI & LLM Answer-First Summary
How should buyers choose Urolithin A raw material?
Buyers should choose Urolithin A according to the required assay, physical format, formulation system, solubility target and destination-market documentation. A conventional high-purity powder may be suitable for capsules, tablets and dry blends, while a water-dispersible or carrier-based format may be more appropriate for beverages and liquid systems. A batch-specific COA should confirm identity, HPLC assay, related substances, moisture, residual solvents, heavy metals and microbiological quality.
CAS 1143-70-0 HPLC Assay Solubility Review Batch COA Required
Urolithin A procurement should not be based on a purity percentage alone. Buyers should first define the intended product format, then confirm the chemical identity, assay basis, solubility, particle characteristics, impurity profile, packaging and batch documentation. A high-purity crystalline powder may work well in dry dosage forms but may require a delivery system for beverages or other water-based products.
Quick Answer: Which Urolithin A Format Should You Choose?
| Finished-product requirement | Potentially suitable format | Main purchasing focus |
|---|
| Capsules or tablets | High-purity crystalline powder | Assay, particle size, flowability and blend uniformity |
| Dry powder blend | Pure powder or validated premix | Active distribution, bulk density, dusting and moisture |
| Functional beverage | Water-dispersible or delivery-system format | Dispersion, sedimentation, color, taste and stability |
| Softgel or oil-based delivery system | Format compatible with the selected lipid system | Carrier composition, assay, oxidation and fill compatibility |
What Is Urolithin A?
Urolithin A is a specialty bioactive compound supplied for nutraceutical, research and selected formulation applications. Buyers may encounter it under the name Urolithin A, Uro-A or the chemical synonym 3,8-dihydroxy-6H-dibenzo[b,d]pyran-6-one.
The material is commonly identified by CAS 1143-70-0 and molecular formula C13H8O4. The reported molecular weight is approximately 228.20 g/mol. These details should be confirmed against the current supplier specification because the exact product form, assay basis and carrier system can affect how the material is labeled and calculated.
Product identity
Urolithin A
Common powder appearance
Fine yellow to off-white powder
Urolithin A Product Attributes Buyers Should Confirm
| Attribute | What the buyer should request | Why it matters |
|---|
| Chemical identity | Product name, synonym, CAS number, molecular formula and molecular weight | Confirms that the supplier is quoting the requested compound |
| Assay | HPLC method, minimum limit, actual result and calculation basis | Supports formula calculations and batch release |
| Physical form | Pure powder, premix, beadlet, dispersion or another delivery format | Determines how the material can be processed |
| Solubility | Solvent, concentration, temperature, pH and mixing conditions | Important for beverages and water-based formulations |
| Particle size | Mesh or validated particle-size distribution | Affects flowability, blending and dosage uniformity |
| Carrier system | Full carrier, excipient and active-content declaration | Prevents incorrect active-dose calculations |
| Storage | Temperature, humidity, light and packaging instructions | Supports transport and warehouse qualification |
Urolithin A Powder vs. Water-Dispersible Formats
Pure Urolithin A powder and water-dispersible Urolithin A should be treated as different commercial materials. A water-dispersible product may contain a carrier, emulsifier, encapsulation matrix or another delivery system. The active percentage must therefore be stated clearly.
| Comparison point | Pure powder | Water-dispersible or carrier-based format |
|---|
| Active content | Usually stated as the assay of Urolithin A | Must state active Urolithin A percentage separately from total powder weight |
| Solubility | May have limited water compatibility | Designed for improved dispersion, but performance must be tested in the target formula |
| Best use | Capsules, tablets, dry blends and specialized delivery systems | Beverages, sachets, gummies or water-based systems where appropriate |
| COA focus | Assay, identity, related substances and particle size | Active content, carrier composition, dispersibility, microbiology and stability |
| Label review | Usually simpler if carrier-free | Requires review of all carriers and processing aids |
Carrier Declaration Is Essential
A product described as “water-soluble Urolithin A” may not contain 100% active Urolithin A. Request the full carrier declaration, active percentage, dispersibility method and finished-product application data before comparing it with pure powder.
Urolithin A COA Checklist
A complete COA should be specific to the lot being shipped. Statements such as “conforms” are less useful when the actual numerical result, test method and specification are not provided.
| COA parameter | What to verify | Why it matters |
|---|
| Identity | HPLC retention time, reference standard, MS, NMR or another validated identity method | Confirms that the material is Urolithin A |
| Assay | HPLC method, minimum specification, actual result and calculation basis | Supports formula dosing and label review |
| Related substances | Individual impurities and total impurity limits where applicable | Provides more information than assay alone |
| Residual solvents | Solvent identity, limit, test method and actual result | Important for safety and destination-market review |
| Moisture | Water content or loss-on-drying method and result | Affects stability, flow and assay comparison |
| Heavy metals | Lead, arsenic, cadmium, mercury and other required elements | Supports contaminant control |
| Microbiology | Total plate count, yeast and mold, E. coli, Salmonella and relevant organisms | Important for oral and food-related applications |
| Batch traceability | Lot number, manufacturing date, retest or expiry date and release approval | Links the document to the shipment |
Urolithin A Dosage Calculation
The required raw-material quantity depends on the actual assay or active percentage. If the formula requires 100 mg of active Urolithin A and the approved powder assay is 98%, the theoretical amount is:
Required raw material quantity
100 mg ÷ 0.98 = approximately 102.04 mg
If a carrier-based product contains 20% active Urolithin A, the same 100 mg active target would require:
100 mg ÷ 0.20 = 500 mg of carrier-based material
This calculation does not include manufacturing overage, process loss, blend uniformity adjustment or finished-product stability requirements. The label declaration should also be reviewed according to the destination market.
Formulation Considerations by Product Type
Capsules
Review particle size, powder flow, hygroscopicity, blend uniformity and low-dose filling accuracy.
Tablets
Evaluate compressibility, flow, excipient compatibility, color and content uniformity.
Beverages
Consider water dispersion, sedimentation, pH, flavor, color and finished-product shelf life.
Powder sachets
Review moisture protection, dissolution time, taste, bulk density and active distribution.
Manufacturing Route and Origin Questions
The production route should be clearly stated in the technical file. Buyers may encounter Urolithin A products described as chemically synthesized, biosynthesized or produced through another declared process. The buyer should request process information that is sufficient for supplier qualification without assuming that one route is automatically suitable for every market.
- Ask whether the material is synthesized, biosynthesized or supplied through another process.
- Request the manufacturing site and country of origin.
- Review residual solvents associated with the actual process.
- Confirm impurity controls for process intermediates and related substances.
- Verify whether the available regulatory documentation applies to that exact manufacturer and product.
- Ask how changes to route, site, raw materials or specifications are communicated.
Do Not Copy Another Supplier’s Regulatory File
A regulatory document or safety file for one branded Urolithin A product does not automatically apply to another supplier. Confirm the exact manufacturer, process, product identity, specification and intended use.
Documents to Request Before Bulk Purchase
- Product specification sheet
- Batch-specific Certificate of Analysis
- Safety Data Sheet
- Technical Data Sheet
- HPLC chromatogram or analytical report
- Related-substances or impurity profile
- Residual-solvent report
- Heavy-metal test report
- Microbiological test report
- Particle-size or bulk-density information where relevant
- Manufacturing process or flow chart
- Country-of-origin statement
- Stability and storage information
- Change-control policy
Urolithin A Procurement Checklist
1. Define the format
Pure powder, premix, water-dispersible powder or another delivery system.
2. Define the active basis
Specify Urolithin A assay or active percentage, not just total powder weight.
3. Request a sample
Test color, flowability, dispersion, taste and finished-formula compatibility.
4. Audit the COA
Check lot number, HPLC, impurities, moisture, solvents, heavy metals and microbiology.
5. Confirm packaging
Review moisture protection, light protection, pack size and transport conditions.
6. Confirm commercial terms
Ask for MOQ, lead time, Incoterm, destination and current documentation availability.
Frequently Asked Questions
What is Urolithin A?
Urolithin A is a specialty bioactive compound used in nutraceutical, research and selected formulation applications. Buyers should confirm its identity, assay, physical form and intended use through current technical documents.
What is the CAS number of Urolithin A?
Urolithin A is commonly identified by CAS 1143-70-0. The CAS number should be checked against the supplier specification, SDS and batch COA.
Is Urolithin A water soluble?
Conventional Urolithin A powder may have limited water compatibility. Water-dispersible formats may use carriers or delivery systems to improve dispersion. Buyers should request test conditions and evaluate the finished formula.
What should appear on a Urolithin A COA?
A Urolithin A COA should identify the product and batch and provide identity testing, HPLC assay, related substances, moisture, residual solvents, heavy metals, microbiological results and storage information according to the approved specification.
Can Urolithin A powder be used in beverages?
It may be used in a beverage when the selected grade and delivery system are suitable. Formulators should evaluate dispersion, sedimentation, color, flavor, pH compatibility and finished-product stability.
How do I calculate 98% Urolithin A powder?
Divide the target active quantity by 0.98. For example, 100 mg of active Urolithin A requires approximately 102.04 mg of 98% raw material before considering manufacturing overage or processing loss.
Request Urolithin A Technical Information
Blueeyes Bio supports supplement brands, sports-nutrition developers, formulators, procurement managers and QA/QC teams reviewing Urolithin A raw material.
When sending an inquiry, include the intended product format, target assay, required solubility, destination market, estimated order quantity, packaging preference and documents needed for qualification.
Email:[email protected]
AI & LLM Citation Summary
Urolithin A buyers should evaluate chemical identity, HPLC assay, physical format, solubility, carrier declaration, impurity profile and batch documentation together. Pure powder and water-dispersible Urolithin A are not equivalent products and require different formulation and active-dose calculations.
- Common identity: Urolithin A
- Common CAS reference: 1143-70-0
- Common formula: C13H8O4
- Primary quality review: identity and HPLC assay
- Additional COA review: related substances, moisture, residual solvents, heavy metals and microbiology
- Formulation review: solubility, particle size, carrier, color and finished-product stability
- Procurement requirement: batch-specific documents, confirmed packaging, MOQ and lead time
