Coix seed extract is the dried and mature seed kernel extract of Coixlachryma jobi L.var.mayuen (Roman.) Stapf., a grass plant. It mainly contains protein, fatty acids, sugars, a small amount of vitamin B1, leucine, and lysine. , arginine, tyrosine, coixin, coixyl, coixolactone, α-β-sitosterol, triterpene compounds.
[Main ingredients]: coixenolide; coixin, protein, sugar, etc.
[Product specifications]: 5:1 10:1 20:1
[Detection method]: UV/TLC
[Product Appearance]: Fine brown powder
[Main functions]: whitening, anti-aging, anti-cancer
药理作用：
1. Anti-cancer effect
Coix seed ethanol extract can inhibit the proliferation of Ehrlich ascites cancer cells and significantly prolong the survival time of mice. In the early days, coix seed ester was considered to be an effective anti-cancer ingredient. Now analysis has confirmed that unsaturated fatty acid (linoleic acid) is the main Anti-cancer ingredients.
2. Inhibitory effect on the central nervous system
Coix seed aqueous extract has an inhibitory effect on pain in mice (hot plate method). Coixin has sedative, analgesic, antipyretic and cooling effects when injected intraperitoneally into mice. Intravenous injection has a sedative effect on mice and rabbits and can inhibit polysynaptic reflexes.
3. Lower blood sugar, blood calcium and blood pressure effects
Subcutaneous injection of ether extract of coix seed (coix seed oil) into rabbits can reduce blood sugar and blood calcium levels. The aqueous extract of coix seed, intraperitoneally injected into mice, can significantly reduce blood sugar concentration. Three Chemicalbook active ingredients were extracted from it, namely coix polysaccharide (A, B, C). These components can cause hypoglycemia in normal mice and mice with alloxan-induced hyperglycemia. Intravenous injection of coixin can cause a temporary decrease in blood pressure in rabbits.
4. Sedative, analgesic and antipyretic effects
Coixin has a weak central inhibitory effect. Intravenous injection of 100 mg/kg coixin into mice can reduce their spontaneous activity and antagonize caffeine. After intravenous injection of 20 mg/kg coixin into rabbits, the electroencephalogram showed a high-amplitude slow-wave cortical inhibitory response. Intraperitoneal injection of 100 mg/kg coixin has an analgesic effect on both mice (tail electrical stimulation method) and rats (radiation Chemicalbook heat method). The water extract of coix seed also has analgesic effect on mice (hot plate method). It also has an antipyretic effect. It has a good antipyretic effect on T.T.G. bacterial fever, but has no effect on the fever caused by dinitrophenol. In addition, intravenous injection of 5 mg/kg coixin had a transient inhibitory effect on polysynaptic reflexes in cat peroneal nerve-gastrocnemius muscle specimens.
5. Enhance immunity and anti-inflammatory effects
Neutral polysaccharides glucan 1-7 and acidic polysaccharides CA-1 and CA-2 obtained from coix seed all show anti-complement activity. After refining coix seed fat, the triglyceride part was extracted from unsaturated fatty acids and administered to prairie dogs. As a result, the IL-1 produced by cells in the peritoneal exudate of the animals in the test group increased 1.5 times compared with the control group, indicating that it has the ability to strengthen humoral immunity. , causing macrophages to produce and secrete ChemicalbookIL-1. The above-mentioned leachate can also significantly enhance the ability of peripheral blood mononuclear cells in healthy people to produce antibodies. Coix seed extract can inhibit the production of reactive oxygen free radicals by human neutrophils, and significantly inhibit the secretion of methyl-converting enzyme, phospholipase A2 and prostaglandin E2 of neutrophils and lymphocytes, indicating that it has certain anti- Inflammation, one of its mechanisms is to stabilize the cell membrane of inflammatory cells.
