N-Desmethyl Sildenafil (UK-92480) | CAS 139755-82-1
Governed by our British technical headquarters and produced via our Asia-based Strategic Alliance, we ensure that every batch meets the rigorous isotopic and chemical purity benchmarks (≥98.5%) required by global CROs and pharmaceutical R&D labs.
We provide comprehensive technical dossiers, including batch-specific COA, 1H-NMR, and LC-MS spectra, to ensure total molecular traceability for your laboratory trials. Request your rapid 24-hour quote today.
N-Desmethyl Sildenafil (UK-92480): The Primary Active Metabolite
"At Blue Eye Bio, we provide the molecular precision required for critical drug metabolism research. N-Desmethyl Sildenafil, also known as UK-92480, is the primary active metabolite of Sildenafil formed during first-pass metabolism in the liver.
1. Detailed Technical Specifications
Parameters | Specification Standard | Method / Note |
Chemical Identity | N-Desmethyl Sildenafil (UK-92480) | -- |
CAS Number | 139755-82-1 | -- |
Molecular Formula | C21H28N6O4S | Theoretical |
Assay (Purity) | ≥ 98.0% / ≥ 99.0% | HPLC Verified |
Appearance | Off-white to Light Yellowish Solid/Powder | Visual |
Characterization | 1H-NMR, LC-MS | Batch-Specific |
Application | Reference Standard / PK-PD Studies | Laboratory Use |
2. Technical Role: Understanding the N-Desmethyl Metabolic Pathway
N-Desmethyl Sildenafil (CAS 139755-82-1) is predominantly produced by the CYP3A4 isoenzyme in human hepatocytes. Although it possesses approximately 50% of the pharmacological potency of the parent compound, its quantification is critical in Pharmacokinetic (PK) and Pharmacodynamic (PD) assessments.
3.R&D Application Scenarios
Bio-analytical Method Development: Acts as the essential calibrator for blood plasma concentration assays in clinical trials.
Bioequivalence (BE) Testing: Utilized by pharmaceutical companies to ensure their generic formulations match the metabolic profile of the reference drug. In-vitro Hepatocyte Research: A reliable tool for studying enzyme induction and metabolic interference in drug-drug interaction (DDI) studies.
4. Why choose Blue Eye Bio for this product?
Unrivaled Analytical Support: Every gram of our N-Desmethyl Sildenafil is governed by our Unified QC Standard (UQS). We don't just supply a powder; we provide a verified molecular fingerprint.
Empowering Emerging Labs: We understand the unique needs of Small and Medium-sized Enterprises and independent labs. We offer Flexible MOQ (available in mg to gram scale) which major industrial giants often overlook. Rapid 24-hour Quoting: Strategic sourcing via our UK-managed alliance allows us to provide technical data and formal quotes within one business day.
Q: Why is the purity of N-Desmethyl Sildenafil more critical than the standard API?
A: As an Analytical Reference Standard, any impurity in UK-92480 can result in signal interference in mass spectrometry (LC-MS). Blue Eye Bio ensures a clean chromatographic profile to eliminate "false positives" in your analytical validation.
Q: Can this metabolite be used for large-scale production? A: CAS 139755-82-1 is primarily a research-grade tool. However, through our Integrated Hub, we can facilitate larger volumes for pilot-scale toxicological studies if required.
Q: Do you provide H-NMR data with the Certificate of Analysis? A: Yes. For professional researchers and Small and Medium-sized Enterprises, we provide batch-specific COA, NMR, and LC-MS spectra to ensure the identity and purity of the compound.
Looking for the stable isotope? Explore our [Sildenafil-D3 & D8 Analytical Standards].
Compare with the parent compound: [Sildenafil Base] (CAS 139755-83-2).
Compliance & Support
